化学性质
属性溶解性Soluble in DMSO and ethanol,Methanol存贮条件储存温度2-8℃描述产品介绍Alamethicin (U-22324) is a polypeptide natural product antibiotic supplied as a mixture of homologs: Alamethicin and Alamethicin I. These compounds form voltage-dependent ion channels in the lipid bilayer, through the spontaneous assembly of units into a multimeric barrel-stave structure spanning the membrane. This formation results in a hydrophilic pore which permits non-specific ion efflux through the membrane. The non-specific ion efflux obliterates the normal electrochemical gradient of the cell, producing the antibiotic property of Alamethicin. Substantiated by experiments with covalently tethered molecules of Alamethicin, It is suggested that different multimeric aggregation states create varying pore sizes with varying stabilities, correlating to differential specificity for ions. This channel-forming activity has been exploited as a tool for introducing hydrophilic small molecules into mitochondria without disrupting the integrity of the membrane.别名丙甲甘肽;Antibiotic U-22324;N-Acetyl-2-methylalanyl-L-prolyl-2-methylalanyl-L-alanyl-2-methylalanyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-valyl-2-methylalanylglycyl-L-leucyl-2-methylalanyl-L-prolyl-L-valyl-2-methylalanyl-2-methylalanyl-L-α-glutamyl-N1-[(2R)-1-hydroxy-3-phenylpropan-2-yl]-L-glutamamide生化机理Monovalent cation ionophore; can mimic nerve action potential across artificial membranes应用Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used for studying membrane interactions of antimicrobial peptides.-----------------------
熔点 :255-270ºC
分子式 :C92H150N22O25
分子量 :1964.31000
精确质量 :1963.11000
PSA :708.13000
LogP :3.96740
外观性状 :固体
储存条件 :
2-8℃
计算化学 :
1、 疏水参数计算参考值(XlogP):-2.6
2、 氢键供体数量:19
3、 氢键受体数量:22
4、 可旋转化学键数量:13
5、 互变异构体数量:1001
6、 拓扑分子极性表面积(TPSA):630
7、 重原子数:119
8、 表面电荷:0
9、 复杂度:3890
10、 同位素原子数量:0
11、 确定原子立构中心数量:0
12、 不确定原子立构中心数量:10
13、 确定化学键立构中心数量:0
14、 不确定化学键立构中心数量:0
15、 共价键单元数量:1
更多 :
1. 性状: 未确定
2. 密度(g/mL,25/4℃):未确定
3. 相对蒸汽密度(g/mL,空气=1):未确定
4. 熔点(℃):未确定
5. 沸点(℃,常压):未确定
6. 沸点(℃,5.2kPa):未确定
7. 折射率:未确定
8. 闪点(℃):未确定
9. 比旋光度(º ):未确定
10. 自燃点或引燃温度(℃):未确定
11. 蒸气压(kPa,25℃):未确定
12. 饱和蒸气压(kPa,60℃):未确定
13. 燃烧热(KJ/mol):未确定
14. 临界温度(℃):未确定
15. 临界压力(KPa):未确定
16. 油水(辛醇/水)分配系数的对数值:未确定
17. 爆炸上限(%,V/V):未确定
18. 爆炸下限(%,V/V):未确定
19. 溶解性:未确定
危险属性
标识符号
GHS06 信号词Danger警示性声明P301 + P310 危害声明H301 个人防护设备Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridgesWGK德国3-----------------------
符号 :
GHS06
信号词 : Danger
危害声明 :H301
警示性声明 :P301 + P310
个人防护装备 : Eyeshields; Faceshields; Gloves; type P2 (EN 143) respirator cartridges
风险声明 (欧洲) :R25
危险品运输编码 :UN 3462 6
闪点(华氏): 188.6 ℉
闪点(摄氏): 87 ℃