中文名称:异绿原酸b
中文同义词:ISOCHLOROGENICACIDB异绿原酸B;异绿原酸B;异绿原酸B(3,4-二咖啡酰奎宁酸);二咖啡酰奎宁酸;ISOCHLOROGENICACIDB异绿原酸B标准品;异绿原酸B(3;3,4-二咖啡酰奎宁酸;3,4-二咖啡酰奎宁酸(异绿原酸B)
英文名称:IsochlorogenicAcidB
英文同义词:IsochlorogenicacidB,froMLonicerajaponica;3,4-Dicaffeoylquinicacid;IsochlorogenicacidB;IsochlorogenicacidB，3,4-Dicaffeoylquinicacid;(1S)-1α,5α-Dihydroxy-3β,4α-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1β-cyclohexanecarboxylicacid;(1S)-4β,5α-Bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1β,3β-dihydroxycyclohexanecarboxylicacid;1β,3β-Dihydroxy-4β,5α-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1α-cyclohexanecarboxylicacid;ISOCHLOROGENICACIDB(RG)
CAS号:14534-61-3
分子式:C25H24O12
分子量:516.45
EINECS号:
异绿原酸b性质
沸点810.8±65.0°C(Predicted)
密度1?+-.0.1g/cm3(Predicted)
储存条件Sealedindry,Storeinfreezer,under-20°C
酸度系数(pKa)3.70±0.50(Predicted)
生物活性
3,4-Dicaffeoylquinic acid 是天然分离的，具有抗氧化，DNA 保护，神经保护和肝保护特性。3,4-Dicaffeoylquinic acid 具有凋亡介导的细胞毒性和 α-葡萄糖苷酶 (α-glucosidase) 抑制作用。3,4-Dicaffeoylquinic acid 具有独特的抗病毒作用机制，即通过增加 TRAIL 来提高病毒清除率。
靶点
Human Endogenous Metabolite
体外研究 3,4-Dicaffeoylquinic acid acts as a greater primary antioxidant than its methanol extract, by having higher ferric reducing activity (EC 50 2.18 μg/ml), β-carotene bleaching activity (EC 50 23.85 μg/ml) and DPPH scavenging activity (EC 50 68.91 μg/ml). 3,4-Dicaffeoylquinic acid exhibits a remarkable dose-dependent inhibitory effect on NCI-H23 (human lung adenocarcinoma) cell lines (EC 50 3.26 μg/ml) and is found to be apoptotic in nature based on a clear indication of DNA fragmentation. 3,4-Dicaffeoylquinic acid also displays a concentration-dependent α-glucosidase inhibition with EC 50 241.80 μg/ml.
化学性质
类色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于金银花，忍冬，杜仲。
