西亚试剂：A Comprehensive Profile of Brain Enzymes that Hydrolyze the

On the cover: 2-arachidonoylglycerol (2-AG) is a lipid signaling molecule that modulates a wide variety of physiological processes through activation of cannabinoid receptors. 2-AG signaling in the nervous system is terminated by enzymatic degradation, but this process has yet to be completely characterized. In this issue, Blankman and colleagues (pp. 1347–1356) describe a functional proteomic strategy to comprehensively survey mammalian brain enzymes that hydrolyze 2-AG. Their results reveal that in addition to the known 2-AG hydrolase monoacylglycerol lipase, two previously uncharacterized enzymes, ABHD6 and ABHD12, make significant contributions to total brain 2-AG hydrolase activity. The cover image depicts a panel of brain enzymes (shown as general α/β-hydrolase fold structures) screened for 2-AG hydrolase activity, with an active enzyme that cleaves 2-AG to arachidonic acid and glycerol highlighted in red. While a human brain is shown on the cover, the study was performed on enzymes enriched from mouse brain. All identified mouse brain 2-AG hydrolases have high-sequence identity orthologs in humans. Background shows primary neurons in culture. Cover art by Gabriel M. Simon.

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