KETOROLAC TROMETHAMINE MSDS报告

化学品及企业标识

PRODUCT NAME

KETOROLAC TROMETHAMINE

NFPA

PRODUCT USE

Analgesic for the short term management of acute, moderate to severe pain, following
surgical procedures. A non- narcotic belonging to the non- steroidal anti- inflammatory
class of drugs. Inhibits the synthesis of prostaglandins and is considered to be a
peripherally acting analgesic. Given by mouth or intravenous injection.

SYNONYMS

C15-H13-N-O3.C4-H11-N-O3, C15-H13-N-O3.C4-H11-N-O3, "1H-pyrrolizine-1-carboxylic acid, 2,
3-dihydro-5-benzoyl-, (+/-)-, compd.", "1H-pyrrolizine-1-carboxylic acid, 2, 3-dihydro-
5-benzoyl-, (+/-)-, compd.", "with 2-amino-2-(hydroxymethyl)-1, 3-propanediol (1:1)",
"with 2-amino-2-(hydroxymethyl)-1, 3-propanediol (1:1)", "(+/-)-2-benzoyl-1-
azabicyclo[3.3.0]-octa-2, 4-diene-6-carboxylic acid, 2-amino-2-hydroxymethane propane-1,
3-diol salt", "(+/-)-2-benzoyl-1-azabicyclo[3.3.0]-octa-2, 4-diene-6-carboxylic acid, 2-
amino-2-hydroxymethane propane-1, 3-diol salt", "ketorolac trometamol", Syntex, Toradol,
"analgesic/ anti-inflammatory NSAID"

CANADIAN WHMIS SYMBOLS

EMERGENCY OVERVIEW

RISK

POTENTIAL HEALTH EFFECTS

ACUTE HEALTH EFFECTS

SWALLOWED

  Although ingestion is not thought to produce harmful effects, the material may still be damaging to the health of the individual following ingestion, especially where pre-  existing organ (e.g. liver, kidney) damage is evident. Present definitions of harmful or toxic substances are generally based on doses producing mortality (death) rather than those producing morbidity (disease, ill-health). Gastrointestinal tract discomfort may produce nausea and vomiting. In an occupational setting however, ingestion of insignificant quantities is not thought to be cause for concern.  

EYE

  Although the material is not thought to be an irritant, direct contact with the eye may produce transient discomfort characterized by tearing or conjunctival redness (as with windburn).  

SKIN

  The material is not thought to produce adverse health effects or skin irritation following contact (as classified using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves be used in an occupational setting.  Open cuts, abraded or irritated skin should not be exposed to this material.  Toxic effects may result from skin absorption.  

INHALED

  Inhalation may produce serious health damage*.  The material is not thought to produce respiratory irritation (as classified using animal models). Nevertheless inhalation of the material, especially for prolonged periods, may produce respiratory discomfort and occasionally, distress.  Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur further disability if excessive concentrations of particulate are inhaled.  

CHRONIC HEALTH EFFECTS

  Principal routes of exposure are by accidental skin and eye contact andinhalation of generated dusts.  Prolonged use of non-steroidal analgesics damages the lining of the gastrointestinal tract, causing ulcers and bleeding. There may be diarrhea or constipation, perforations causing serious infection, and blood in the vomit or stools. Kidney damage can result in blood or pus in the urine, changes in urine chemistry, change in the frequency of urination, insufficiency of kidney function, destruction of the kidney lining and kidney inflammation. Occasionally, the liver may be affected, causing inflammation (hepatitis) and jaundice. There may be changes in blood cell distribution, and disturbance in platelet function. Sensitivity to light may occur. Anaphylatic-like syndrome is characterized by rash with redness, spots and blisters, itching, and fainting. The eyes, ears and urinary tract can all be affected. Asthma and anemia may be exacerbated. These drugs can cause circulatory defects in the fetus and newborn. Once the kidney has been damaged, there is an increased likelihood that cancers could develop there.  Chronic ingestion of excessive amounts of non-narcotic analgesics can lead to nephropathy (kidney damage) in humans. A substantial number of health deficits are associated with this condition. The include reduced GFR (glomerular filtration rate), salt wastage, hyperkalaemia, metabolic acidosis, and a vasopressin-resistant concentration defect. More severe forms of analgesic nephropathy may lead to papillary necrosis with sloughing of the papilla. Although renal function may return to normal after discontinuation of treatment or abuse, complete anuria (absence of urine formation) may result following continued abuse.  Most patients who develop analgesic nephropathy consume analgesics for up to 3 years, consuming between 2 and 5 mg daily.  

成分及组成信息

危险性质描述

急救措施

消防措施

泄露应急处理

处理和储存

接触控制

理化特性

稳定性和反应活性

毒理学信息

生态学资料

废弃处理

运输信息

法规信息

其他信息