西亚试剂:Functional heterogeneity of human memory CD4+ T cell clones

Functional heterogeneity of human memory CD4+ T cell clones primed by pathogens or vaccines

Simone Becattini, Daniela Latorre, Federico Mele, Mathilde Foglierini, Corinne De Gregorio, Antonino Cassotta, Blanca Fernandez, Sander Kelderman, Ton N. Schumacher, Davide Corti, Antonio Lanzavecchia, Federica Sallusto

Distinct types of CD4+ T cells protect the host against different classes of pathogens. However, it is unclear whether a given pathogen induces a single type of polarized T cell. By combining antigenic stimulation and T cell receptor deep sequencing, we found that human pathogen- and vaccine-specific T helper 1 (TH1), TH2, and TH17 memory cells have different frequencies but comparable diversity and comprise not only clones polarized toward a single fate, but also clones whose progeny have acquired multiple fates. Single na?ve T cells primed by a pathogen in vitro could also give rise to multiple fates. Our results unravel an unexpected degree of interclonal and intraclonal functional heterogeneity of the human T cell response and suggest that polarized responses result from preferential expansion rather than priming.

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