西亚试剂:Another Pfizer blockbuster bites the dust as Celebrex gener

Look out, Pfizer--the generics are here. Both Teva and Mylan Wednesday launched versions of the company's arthritis med Celebrex, meaning Pfizer is about to watch the sales decline of yet another blockbuster.

Each of the companies is rolling out generics of the $2.56 billion U.S. seller at strengths of 50 mg, 100 mg, 200 mg, and 400 mg, they said. With generics makers usually pricing their products 30% to 80% lower than their branded counterparts, the Pfizer stalwart--its fourth-best seller--is in for a top-line slide.

Pfizer has a March court decision to thank for the impeding hit. Last March, a U.S. patent office reissued a key IP shield on the drug, extending the company's market exclusivity through the end of 2015. But a year later, a U.S. court struck that decision down, opening Celebrex up to generic rivals. Bad news for Pfizer, where Celebrex trails only Lyrica, the Prevnar franchise and Enbrel in the company's sales ranks--and Celebrex generates the vast majority of its global sales in the U.S.

The pharma giant has watched the patent cliff spell doom for a top product more than once, of course. Heavyweight Lipitor saw its sales pummeled by low-cost competition after losing protection. Though Viagra still has a lock on the U.S. market, it's facing generics overseas.

And while the company is working to whip its pipeline into shape, it's lately seemed to be late to every party: Its PCSK9 candidate is currently the furthest away from the market, for example, and it's beginning to dabble in immuno-oncology well behind peers Merck and Bristol-Myers Squibb.

That's one of the reasons the company has been scouting out deals--like the whopper of a proposed merger that AstraZeneca shot down earlier this year. Some analysts say they haven't ruled out the possibility that Pfizer comes back for another pass at its British peer, while others have listed Actavis--despite that company's own recent agreement join forces with Allergan--as a back-up target.· 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询