西亚试剂：Observations like these suggest that various types of human

Observations like these suggest that various types of human cancers opportunistically upregulate specific early embryonic transcription factors in order to gain many of the attributes of the cells associated with high-grade malignancy. By activating these normally latent transcription factors, cancer cells gain access to their pleiotropic activities and thus are able to acquire the multiple traits associated with the EMT and invasiveness in a single step.

Research does not yet reveal how expression of these various transcription factors is induced. Nonetheless there is clear evidence that carcinoma cells in the epithelial compartment of a tumor receive various signals from the nearby reactive stroma that causes some of the transcription factors to be expressed in the carcinoma cells, enabling them to activate the EMT and acquire invasive and metastatic powers. Our current research is focused on uncovering the signals that are involved in inducing expression of these transcription factors and the mechanisms that enable them to communicate with one another.

TAN INCE M.D. Ph.D.
Instructor, Department of Pathology, Harvard Medical School
Associate Pathologist, Department of Pathology, Brigham and Women's Hospital
DF/HCC Program Affiliation
Member, Breast Cancer Program

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