西亚试剂：Effects of Gekko sulfated polysaccharide on the proliferati

Effects of Gekko sulfated polysaccharide on the proliferation and differentiation of hepatic cancer cell line

Auteur(s) / Author(s)

XIONGZHI WU ; DAN CHEN ; XIE Guang-Ru ;

Résumé / Abstract

Gekko swinhonis Guenther has been used as an anti-cancer drug in traditional Chinese medicine. Gekko sulfated polysaccharide (Gepsin) was investigated for its activity in hepatocellular carcinoma. Hepatocarcinoma cell line (Bel-7402) and liver cell line (L-02) were exposed to Gepsin (100 μg/ml and 10 μg/ml). Gepsin did not suppress the proliferation and viability of normal liver L-02 cells, but strongly inhibited the proliferation of hepatocarcinoma Bel-7402 cells. Gepsin did not induce the apoptosis of Bel-7402 cells, but blocked cells in G[2]/M phase. Treated with Gepsin, Bel-7402 cells showed ultrastructural features of differentiation. AFP secretion decreased while ALB secretion increased markedly on Gepsin-treated cells. The data show that Gepsin suppressed the proliferation and induced differentiation of hepatocarcinoma, but the toxicity to normal liver cells was negligible.

Revue / Journal Title

Cell biology international  (Cell biol. intern.)  ISSN 1065-6995 

Source / Source

2006, vol. 30, no8, pp. 659-664 [6 page(s) (article)]

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