西亚试剂：Proliferative Changes in the Bronchial Epithelium of Former

Proliferative Changes in the Bronchial Epithelium of Former Smokers Treated With Retinoids

Walter N. Hittelman, Diane D. Liu, Jonathan M. Kurie, Reuben Lotan, Jin Soo Lee, Fadlo Khuri, Heladio Ibarguen, Rodolfo C. Morice, Garrett Walsh, Jack A. Roth, John Minna, Jae Y. Ro, Anita Broxson, Waun Ki Hong, J. Jack Lee

Affiliations of authors: Department of Experimental Therapeutics (WNH, HI), Department of Biostatistics (JJL, DDL), Department of Thoracic/Head and Neck Medical Oncology (JMK, JSL, RL, FK, AB, WKH), Department of Pulmonary Medicine (RCM), Department of Thoracic and Cardiovascular Surgery (GW, JAR), Department of Pathology (JYR), University of Texas M. D. Anderson Cancer Center, Houston, TX; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX (JM)

Correspondence to: Walter N. Hittelman, PhD, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Box 19, 1515 Holcombe Blvd, Houston, TX 77030 (e-mail: ).

Background: Retinoids have shown antiproliferative and chemopreventive activity. We analyzed data from a randomized, placebo-controlled chemoprevention trial to determine whether a 3-month treatment with either 9-cis-retinoic acid (RA) or 13-cis-RA and ${alpha}$ -tocopherol reduced Ki-67, a proliferation biomarker, in the bronchial epithelium.

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