西亚试剂：Induction of Pluripotent Stem Cells from Adult Human Fibrob

Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,1 Koji Tanabe,1 Mari Ohnuki,1 Megumi Narita,1,2 Tomoko Ichisaka,1,2 Kiichiro Tomoda,3
and Shinya Yamanaka1,2,3,4,*
1Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan
2CREST, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan
3Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
4Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto 606-8507, Japan
*Correspondence:
SUMMARY
Successful reprogramming of differentiated human somatic cells into a pluripotent state would allow creation of patient- and disease-specific stem cells. We previously reported generation of induced pluripotent stem (iPS) cells, capable
of germline transmission, from mouse somatic cells by transduction of four defined transcription factors. Here, we demonstrate the generation of iPS cells from adult human dermal fibroblasts with the same four factors: Oct3/4,
Sox2, Klf4, and c-Myc. Human iPS cells were similar to human embryonic stem (ES) cells in morphology, proliferation, surface antigens, gene expression, epigenetic status of pluripotent cell-specific genes, and telomerase activity.
Furthermore, these cells could differentiate into cell types of the three germ layers in vitro and in teratomas. These findings demonstrate that iPS cells can be generated from adult human fibroblasts.

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