西亚试剂：Differentiation-Defective Stem Cells Outcompete Normal Stem

Differentiation-Defective Stem Cells Outcompete Normal Stem Cells for Niche Occupancy in the Drosophila Ovary

Zhigang Jin,1,3 Daniel Kirilly,1,2,3 Changjiang Weng,1 Eihachiro Kawase,1 Xiaoqing Song,1 Sarah Smith,1 Joel Schwartz,1 and Ting Xie1,2,

1 Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
2 Department of Anatomy and Cell Biology, University of Kansas School of Medicine, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA

Corresponding author
Ting Xie
Summary

Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche occupancy in a cadherin-dependent manner. The differentiation-defective bam or bgcn mutant GSCs invade the niche space of neighboring wild-type GSCs and gradually push them out of the niche by upregulating E-cadherin expression. Furthermore, the bam/bgcn-mediated GSC competition requires E-cadherin and normal GSC division, but not the self-renewal-promoting BMP niche signal, while different E-cadherin levels can sufficiently stimulate GSC competition. Therefore, we propose that GSCs have a competitive relationship for niche occupancy, which may serve as a quality control mechanism to ensure that accidentally differentiated stem cells are rapidly removed from the niche and replaced by functional ones.

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