西亚试剂：Beta-catenin stabilization extends regulatory T cell surviv

Beta-catenin stabilization extends regulatory T cell survival and induces anergy in nonregulatory T cells

Yi Ding1,2, Shiqian Shen1, Andreia C Lino1, Maria A Curotto de Lafaille1,3 & Juan J Lafaille1,3

Abstract

-catenin is a central molecule in the Wnt pathway. Expression of a stable form of -catenin on CD4+CD25+ regulatory T (Treg) cells resulted in a marked enhancement of survival of these cells in vitro. Furthermore, stable -catenin–expressing CD4+CD25+ Treg cells outcompeted control Treg cells in vivo, and the number of Treg cells necessary for protection against inflammatory bowel disease could be substantially reduced when stable -catenin–expressing CD4+CD25+ Treg cells were used instead of control Treg cells. Expression of stable -catenin on potentially pathogenic CD4+CD25- T cells rendered these cells anergic, and the -catenin–mediated induction of anergy occurred even in Foxp3-deficient T cells. Thus, through enhanced survival of existing regulatory T cells, and through induction of unresponsiveness in precursors of T effector cells, -catenin stabilization has a powerful effect on the prevention of inflammatory disease.