西亚试剂：Otefin, a Nuclear Membrane Protein, Determines the Fate of

Otefin, a Nuclear Membrane Protein, Determines the Fate of Germline Stem Cells in Drosophila via Interaction with Smad Complexes

Xiaoyong Jiang,1,2,3 Laixin Xia,1,2,3 Dongsheng Chen,1,2,3 Yingyue Yang,1,2 Haidong Huang,1,2 Lele Yang,1 Qiudong Zhao,1 Lijun Shen,1 Jun Wang,1 and Dahua Chen1,

1 State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, 25 Beisihuanxi Road, Haidian, Beijing, 100080, China
2 Graduate School, Chinese Academy of Sciences, 25 Beisihuanxi Road, Haidian, Beijing, 100080, China

Summary
Nuclear envelope proteins play important roles in chromatin organization, gene regulation, and signal transduction; however, the physiological role of these proteins remains elusive. We found that otefin (ote), which encodes a nuclear lamin, is essential for germline stem cell (GSC) maintenance. We show that Ote, as an intrinsic factor, is both necessary and sufficient to regulate GSC fate. Furthermore, we demonstrate that ote is required for the Dpp/BMP signaling pathway to silence bam transcription. By structure-function analysis, we demonstrate that the nuclear membrane localization of Ote is essential for its role in GSC maintenance. Finally, we show that Ote physically interacts with Medea/Smad4 at the bam silencer element to regulate GSC fate. Thus, we demonstrate that specific nuclear membrane components mediate signal-dependent transcriptional effects to control stem cell behavior.

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