西亚试剂：Small-molecule activation of neuronal cell fate

Small-molecule activation of neuronal cell fate
Jay W Schneider1, Zhengliang Gao2, Shijie Li3, Midhat Farooqi3, Tie-Shan Tang4, Ilya Bezprozvanny4, Doug E Frantz5 & Jenny Hsieh2

We probed an epigenetic regulatory path from small molecule to neuronal gene activation. Isoxazole small molecules triggered robust neuronal differentiation in adult neural stem cells, rapidly signaling to the neuronal genome via Ca2+ influx. Ca2+-activated CaMK phosphorylated and mediated nuclear export of the MEF2 regulator HDAC5, thereby de-repressing neuronal genes. These results provide new tools to explore the epigenetic signaling circuitry specifying neuronal cell fate and new leads for neuro-regenerative drugs.

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