西亚试剂：The Growth Factor Environment Defines Distinct Pluripotent

The Growth Factor Environment Defines Distinct Pluripotent Ground States in Novel Blastocyst-Derived Stem Cells

Yu-Fen Chou1,7,Hsu-Hsin Chen1,7,Maureen Eijpe2,7,Akiko Yabuuchi3,Joshua G. Chenoweth4,Paul Tesar5,Jun Lu6,Ronald D.G. McKay4andNiels Geijsen1,,

1 Harvard Stem Cell Institute, Massachusetts General Hospital, Center for Regenerative Medicine, CPZN  4256, 185 Cambridge Street, Boston, MA 02114, USA
2 Erasmus Medical Centre, Department of Cell Biology, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
3 Division of Pediatric Hematology/Oncology, Children's Hospital Boston, One Blackfan Circle, Boston, MA, 02115, USA
4 Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
5 Department of Genetics, Case Western Reserve University, 2109 Adelbert Road BRB-725, Cleveland, OH 44106, USA
6 The Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02141, USA
7 These authors contributed equally to this work

SUMMARY

Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the postimplantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remarkably, ES cells and EpiSCs display profound differences in the combination of growth factors that maintain their pluripotent state. Molecular and functional differences between these two stem cell types demonstrate that the tissue of origin and/or the growth factor milieu may be important determinants of the stem cell identity. We explored how developmental stage of the tissue of origin and culture growth factor conditions affect the stem cell pluripotent state. Our findings indicate that novel stem cell lines, with unique functional and molecular properties, can be generated from murine blastocyst embryos. We demonstrate that the culture growth factor environment and cell-cell interaction play a critical role in defining several unique and stable stem cell ground states.

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