西亚试剂：Differential Mobilization of Subsets of Progenitor Cells fr

Differential Mobilization of Subsets of Progenitor Cells from the Bone Marrow

Simon C. Pitchford1,Rebecca C. Furze1,Carla P. Jones1,Antje M. Wengner1andSara M. Rankin1,,

1 Leukocyte Biology Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK

Summary

G-CSF stimulates mobilization of hematopoietic progenitor cells (HPCs) from bone marrow by disrupting the CXCR4/SDF-1α retention axis. We show here that distinct factors and mechanisms regulate the mobilization of endothelial (EPCs) and stromal progenitor cells (SPCs). Pretreatment of mice with VEGF did not disrupt the CXCR4/SDF-1α chemokine axis but stimulated entry of HPCs into the cell cycle via VEGFR1, reducing their migratory capacity invitro and suppressing their mobilization invivo. In contrast, VEGF pretreatment enhanced EPC mobilization via VEGFR2 in response to CXCR4 antagonism. Furthermore, SPC mobilization was detected when the CXCR4 antagonist was administered to mice pretreated with VEGF, but not G-CSF. Thus, differential mobilization of progenitor cell subsets is dependent upon the cytokine milieu that regulates cell retention and proliferation. These findings may inform studies investigating mechanisms that regulate progenitor cell recruitment in disease and can be exploited to provide efficacious stem cell therapy for tissue regeneration.

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