西亚试剂：Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cel

Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cells to Differentiate into CD8+ T Lymphocytes in Lung Tissue via Up-Regulating Notch1 Expression

Zhuohan Zhang1, Bin Zeng1, Zhiqian Zhang1, Guohui Jiao1, Haijie Li1, Zhizi Jing1, Jiangbo Ouyang1, Xin Yuan1, Limin Chai1, Yongzhe Che2, Yuan Zhang1 and Rongcun Yang1,3

Departments of 1 Immunology and 2 Pathology, Nankai University School of Medicine; 3 Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, People's Republic of China

Suppressor of cytokine signaling 3 (SOCS3) expression in bone marrow cells (BMC) was up-regulated upon exposure to interleukin 6, lipopolysaccharide, or tumor-associated factors. But, how the up-regulated SOCS3 affects differentiation of BMCs is incompletely characterized. Here, we showed that SOCS3 promoted BMCs to intently differentiate into CD8 T cells. Importantly, lung can be as one athymus tissue for the BMCs to differentiate into CD8+ T cells. Notch1 plays a critical role in the differentiation from SOCS3-transfected BMCs to CD8+ T cells. We conclude that the up-regulated SOCS3 in some pathologic conditions, such as tumor and inflammation, might promote BMCs to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression. This may represent a new mechanism against diseases such as tumor.

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