西亚试剂：Genetic analysis of radiation-induced changes in human gene

Genetic analysis of radiation-induced changes in human gene expression

Denis A. Smirnov1, Michael Morley2, Eunice Shin2, Richard S. Spielman3 & Vivian G. Cheung1,2,3,4

1 Howard Hughes Medical Institute,
2 The Children's Hospital of Philadelphia,
3 Department of Genetics and,
4 Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

Humans are exposed to radiation through the environment and in medical settings. To deal with radiation-induced damage, cells mount complex responses that rely on changes in gene expression. These gene expression responses differ greatly between individuals1 and contribute to individual differences in response to radiation2. Here we identify regulators that influence expression levels of radiation-responsive genes. We treated radiation-induced changes in gene expression as quantitative phenotypes3, 4, and conducted genetic linkage and association studies to map their regulators. For more than 1,200 of these s there was significant evidence of linkage to specific chromosomal regions. Nearly all of the regulators act in trans to influence the expression of their target genes; there are very few cis-acting regulators. Some of the trans-acting regulators are transcription factors, but others are genes that were not known to have a regulatory function in radiation response. These results have implications for our basic and clinical understanding of how human cells respond to radiation.

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