西亚试剂：The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

Rui Benedito1,2,Cristina Roca1,Inga S?rensen3,Susanne Adams1,2,Achim Gossler3,Marcus Fruttiger4andRalf H. Adams1,2,,

1 Cancer Research UK London Research Institute, Vascular Development Laboratory, London WC2A 3PX, UK
2 Max Planck Institute for Molecular Biomedicine, Department Tissue Morphogenesis and University of Münster, Faculty of Medicine, Münster 48149, Germany
3 Institute for Molecular Biology OE5250, Medizinische Hochschule Hannover, Hannover D-30625, Germany
4 Institute of Ophthalmology, University College London, London EC1V 9EL, UK

The Notch pathway is a highly conserved signaling system that controls a diversity of growth, differentiation, and patterning processes. In growing blood vessels, sprouting of endothelial tip cells is inhibited by Notch signaling, which is activated by binding of the Notch receptor to its ligand Delta-like 4 (Dll4). Here, we show that the Notch ligand Jagged1 is a potent proangiogenic regulator in mice that antagonizes Dll4-Notch signaling in cells expressing Fringe family glycosyltransferases. Upon glycosylation of Notch, Dll4-Notch signaling is enhanced, whereas Jagged1 has weak signaling capacity and competes with Dll4. Our findings establish that the equilibrium between two Notch ligands with distinct spatial expression patterns and opposing functional roles regulates angiogenesis, a mechanism that might also apply to other Notch-controlled biological processes.

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