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Variation in the safety of induced pluripotent stem cell lines
Kyoko Miura1,2,3,4, Yohei Okada4,5, Takashi Aoi1,3, Aki Okada1,3, Kazutoshi Takahashi1,3, Keisuke Okita1,3, Masato Nakagawa1,2,3, Michiyo Koyanagi1,3, Koji Tanabe1,2,3, Mari Ohnuki1,2,3, Daisuke Ogawa4, Eiji Ikeda6, Hideyuki Okano4 & Shinya Yamanaka1,2,3,7
We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast–derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.
1 Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.
2 Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
3 Yamanaka iPS Cell Special Project, Japan Science and Technology Agency, Kawaguchi, Japan.
4 Department of Physiology, School of Medicine, Keio University, Tokyo, Japan.
5 Kanrinmaru-Project, School of Medicine, Keio University, Tokyo, Japan.
6 Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
7 Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA.
