西亚试剂：Generation of pluripotent stem cells from patients with typ

Generation of pluripotent stem cells from patients with type 1 diabetes

René Maehra, Shuibing Chena, Melinda Snitowa, Thomas Ludwigb, Lisa Yagasakia, Robin Golandc, Rudolph L. Leibelc and Douglas A. Meltona,1

aDepartment of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138; and
bDepartment of Pathology and Cell Biology, and
cDivision of Molecular Genetics and Naomi Barrie Diabetes Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032

Type 1 diabetes (T1D) is the result of an autoimmune destruction of pancreatic β cells. The cellular and molecular defects that cause the disease remain unknown. Pluripotent cells generated from patients with T1D would be useful for disease modeling. We show here that induced pluripotent stem (iPS) cells can be generated from patients with T1D by reprogramming their adult fibroblasts with three transcription factors (OCT4, SOX2, KLF4). T1D-specific iPS cells, termed DiPS cells, have the hallmarks of pluripotency and can be differentiated into insulin-producing cells. These results are a step toward using DiPS cells in T1D disease modeling, as well as for cell replacement therapy.

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