西亚试剂：Starvation Protects Germline Stem Cells and Extends Reprodu

Starvation Protects Germline Stem Cells and Extends Reproductive Longevity in C. elegans

Giana Angelo 1 and Marc R. Van Gilst 1*

1 Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA.

Study of starvation-resistant biological programs has elucidated numerous mechanisms influencing aging. Here, we present the discovery and characterization of starvation-induced adult reproductive diapause (ARD) in C. elegans. ARD differs from the C. elegans dauer diapause in that it enables sexually mature adults to delay reproductive onset 15-fold and extend total adult lifespan at least 3-fold. Effectiveness of ARD requires apoptotic death of the entire germline, except for a small population of protected germline stem cells (GSCs). Upon refeeding, surviving GSCs regenerate a new germline capable of offspring production near the level of nonstarved animals. The starvation-sensing nuclear receptor NHR-49 is required for ARD entry and recovery. Our findings establish mechanisms for preserving stem cell potency and reproductive potential during prolonged starvation.

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