西亚试剂：IL-1β enhances the antibacterial activity of astrocytes by

IL-1β enhances the antibacterial activity of astrocytes by activation of NF-κB

Yulei Xia, Qiwei Zhai *

Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai, China

Astrocytes have important immune functions in CNS, and astrocytes stimulated by interferon- were showed to have direct antimicrobial function. However whether astrocytes without the stimulation of cytokines have antibacterial function, and how this function is regulated are still largely unknown. In this study, we found that primary cultured astrocytes inhibited the growth of both gram-negative and gram-positive bacteria. Further more, we showed that interleukin-1β (IL-1β) enhanced the antibacterial effect in a dose-dependent manner, and the antibacterial effect of astrocytes from IL-1β receptor-deficient mice failed to be enhanced by IL-1β. IL-1β stimulated IB degradation, NF-κB nuclear translocation, and transactivation in astrocytes. NF-κB inhibitors blocked NF-B activation and the enhanced antibacterial effect induced by IL-1β. In addition, overexpression of dominant negative IB in astrocytes inhibited IB degradation and NF-B transactivation, and also inhibited the enhanced antibacterial effect induced by IL-1β. All these data demonstrated that IL-1β enhanced the antibacterial activity of astrocytes by activation of NF-κB

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