西亚试剂：Cdc42-Mediated Tubulogenesis Controls Cell Specification

Cdc42-Mediated Tubulogenesis Controls Cell Specification

Gokul Kesavan1, Fredrik Wolfhagen Sand1, Thomas Uwe Greiner1, Jenny Kristina Johansson1, Sune Kobberup1, Xunwei Wu2, Cord Brakebusch2 and Henrik Semb1, ,

1 Stem Cell and Pancreas Developmental Biology, Stem Cell Center, Lund University, BMC, SE-22184 Lund, Sweden
2 Biomedical Institute, BRIC, University of Copenhagen, 2100 Copenhagen, Denmark

Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether these two processes are independently controlled, or whether proper cell specification depends on formation of tubes. To address these fundamental questions, we have studied the functional role of Cdc42 in pancreatic tubulogenesis. We present evidence that Cdc42 is essential for tube formation, specifically for initiating microlumen formation and later for maintaining apical cell polarity. Finally, we show that Cdc42 controls cell specification non-cell-autonomously by providing the correct microenvironment for proper control of cell-fate choices of multipotent progenitors.For a video summary of this article, see the PaperFlick file with the Supplemental Data available online.

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