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Intracellular Silicon Chips in Living Cells
Rodrigo Gómez-Martínez 1 *, Patricia Vázquez 2 *, Marta Duch 1, Alejandro Muriano 3, Daniel Pinacho 3, Nuria Sanvicens 3, Francisco Sánchez-Baeza 3, Patricia Boya 2, Enrique J. de la Rosa 2, Jaume Esteve 1, Teresa Suárez 2 *§, José A. Plaza 1 *§
1Instituto de Microelectrónica de Barcelona IMB-CNM (CSIC) Campus UAB s/n Cerdanyola, 08193 Barcelona (Spain)
2Centro de Investigaciones Biológicas, CIB (CSIC) C/Ramiro de Maeztu 9, 28040 Madrid (Spain)
3Instituto de Investigaciones Químicas y Ambientales de Barcelona IIQAB (CSIC) C/Jorge Girona, 18-26, 08034 Barcelona (Spain)
Silicon-based chips offer high flexibility and versatility as they are based on semiconductor and MEMS technology. They can be top-down fabricated with well-controlled shape and size. Silicon microchips can be internalized into eukaryotic cells (see image) without interfering with cell viability. Engineered intracellular chips with different biomolecules attached to the surface can be used as intracellular sensors.
