西亚试剂：Two immunoregulatory peptides with antioxidant activity fro

Two immunoregulatory peptides with antioxidant activity from tick salivary glands
Jing Wu1, Yipeng Wang1, Han Liu1, Hailong Yang1, Dongying Ma1, Jianxu Li1, Dongsheng Li1, Ren Lai1 and Haining Yu2,*

1 Kunming Institute of Zoology, Chinese Academy of Sciences, China;
2 Dalian University of Technology, China

Ticks are blood feeding arthropods that may secrete immunosuppressant molecules, which inhibit host inflammatory and immune responses and provide survival advantages to pathogens at tick bleeding sites in hosts. In current work, two families of immunoregulatory peptides, hyalomin A and B were firstly identified from salivary glands of hard tick Hyalomma asiaticum asiaticum. Three copies of them are encoded by identical gene and released from the same protein precursor. Both hyalomin A and B can exert significant antiinflammatory functions, either by directly inhibiting the host secretion of inflammatory factors such as TNF alpha, MCP1 and IFN gamma, or by indirectly increasing the secretion of immunosuppressant cytokine of IL10. Hyalomin A and B were both found to potently scavenge free radical in vitro in a rapid manner, and inhibited adjuvant induced inflammation in mouse models in vivo. The JNK SAPK subgroup of MAPKs signaling pathway was involved in such immunoregulatory functions of hyalomin A and B. These results showed that immunoregulatory peptides of tick salivary glands suppress host inflammatory response by modulating cytokine secretion and detoxifying reactive oxygen species

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