西亚试剂：Mice Cloned from Induced Pluripotent Stem Cells (iPSC)

Mice Cloned from Induced Pluripotent Stem Cells (iPSC)
Zhaohui Kou, Lan Kang, Ye Yuan, Yu Tao, Yu Zhang, Tong Wu, Jing He, Jianle Wang, Zhonghua Liu and Shaorong Gao

Differentiated somatic cells of various species could be reprogrammed into induced pluripotent stem cells (iPSC) by ectopically expressing a combination of several transcription factors which are highly enriched in embryonic stem cells (ESC). The generation of iPS cells in large animals has raised the possibility of producing genetically modified large animals through nuclear transplantation approach. However, it remains unknown whether iPSC could be used for generating cloned animals through nuclear transfer method. Here, we show the successful production of viable cloned mice from inducible iPSC through nuclear transfer approach, and the efficiency is similar to using ESC derived via normal fertilization. Furthermore, the cloned mice are fertile and can produce second-generation offspring. These efforts strengthened the possibility of utilizing iPSC to generate gene modified large animals for pharmaceutical purposes in the future.

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