西亚试剂：Identification of Germline Stem Cells in the Ovary of the T

Identification of Germline Stem Cells in the Ovary of the Teleost Medaka
Shuhei Nakamura,1 Kayo Kobayashi,1 Toshiya Nishimura,1,2 Shin-ichi Higashijima,3,4 Minoru Tanaka1,2,*

Germline stem cells continually produce sperm in vertebrate testes, whereas there is no direct evidence showing that germline stem cells are present in adult vertebrate ovaries. Using transgenic methods and clonal analysis, we identified germline stem cells that supported oogenesis and the production of offspring in the ovaries of adult medaka fish. Early-stage germ cells were localized in clusters along interwoven threadlike cords of sox9b-expressing somatic cells (termed "germinal cradles") where the germ cells developed. Germline stem cells gave rise to germ cells that divided to produce cysts, which then underwent cell death or separated to form follicles. Our results provide insight into germline stem cell biology of medaka and provide a model system for studying vertebrate stem cell niches.

1 Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan.
2 Department of Basic Biology, Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8585, Japan.
3 National Institutes of Natural Sciences, Okazaki Institute for Integrative Bioscience, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan.
4 Department of Physiological Sciences, Graduate University for Advanced Studies (SOKENDAI), Okazaki, Aichi 444-8585, Japan.

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