西亚试剂：granulocyte colony stimulating factor (G-CSF)-mobilized CD3

Recently, granulocyte colony stimulating factor (G-CSF)-mobilized CD34+ blood cells have been used as a source from which to derive iPSCs (Loh et al., 2009). However, this requires the subcutaneous injection of G-CSF, a process that can be applied only if the donor is in good medical condition. Also, the negative effects of treatment of patients with growth factors such as erythropoietin (Miller et al., 2009) and G-CSF are still being investigated. Of concern is the use of G-CSF because this cytokine is a growth factor for myeloid cell precursors (Touw and van de Geijn, 2007) and because G-CSF treatment of patients with severe congenital neutropenia (SCN) can result in a truncated G-CSF receptor allele and acute myeloid leukemia transformation (Touw, 1997). Derivation of iPSCs from peripheral mononuclear blood cells would circumvent all these issues; in addition, peripheral blood is the most accessible adult tissue and permits access to numerous frozen samples already stored at blood banks. Such samples could be expanded in culture and reprogrammed to iPSCs, which in turn allows researchers to study the molecular mechanism underlying blood and other disorders. We show here the derivation of iPSC clones from mature peripheral blood T and myeloid cells.

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