西亚试剂：Somatic cells can be induced to the pluripotent state

Somatic cells can be induced to the pluripotent state by the enforced expression of several transcription factors including OCT4, SOX2, KLF4, MYC, NANOG, and LIN28 (Takahashi et al., 2007,Yu et al., 2007,Park et al., 2008a). Human iPSCs are commonly generated from dermal fibroblasts harvested by surgical skin biopsy (Park et al., 2008b). Exposure of the dermis to ultraviolet light increases the risk for chromosomal aberrations (Ikehata et al., 2003), raising concerns for whether iPSCs will reflect the patient's constitutional genotype. For routine clinical application, it would be desirable to reprogram cell types that are safe and can be collected noninvasively in large numbers.

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