西亚试剂：In vivo angiogenesis imaging of solid tumors by vβ3-targete

In vivo angiogenesis imaging of solid tumors by vβ3-targeted, dual-modality micellar nanoprobes
Chase W Kessinger1, Chalermchai Khemtong1, Osamu Togao2, Masaya Takahashi2, Baran D Sumer3 and Jinming Gao1

1 Department of Pharmacology, Harold C Simmons Comprehensive Cancer Center
2 Advanced Imaging Research Center
3 Department of Otolaryngology, University of Texas Southwestern Medical Center at Dallas, ND2.210, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA

The objective of this study was to develop and evaluate an vβ3-specific nanoprobe consisting of fluorescent superparamagnetic polymeric micelles (FSPPM) for in vivo imaging of tumor angiogenesis. Spherical micelles were produced using poly(ethylene glycol)-b-poly(D,L-lactide) co-polymers conjugated with tetramethylrhodamine, a fluorescent dye, and loaded with superparamagnetic iron oxide nanoparticles. The resulting micelle diameter was 50–70 nm by dynamic light scattering and transmission electron microscopy measurements. Micelles were encoded with an vβ3-specific peptide, cyclic RGDfK, and optimized for maximum fluorescence and targeting in vβ3-overexpressing cells in vitro. In mice, cRGD-FSPPM-treated animals showed vβ3-specific FSPPM accumulation in human lung cancer subcutaneous tumor xenografts. Together with the histological validation, the three-dimensional gradient echo magnetic resonance imaging (MRI) data provide high spatial resolution mapping and quantification of angiogenic vasculature in an animal tumor model using targeted, ultrasensitive MRI nanoprobes.

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