西亚试剂：Mechanical regulation of cell function with geometrically m

Mechanical regulation of cell function with geometrically modulated elastomeric substrates
Jianping Fu1,2,3, Yang-Kao Wang1,2,3, Michael T Yang1, Ravi A Desai1, Xiang Yu1, Zhijun Liu1 & Christopher S Chen1

We report the establishment of a library of micromolded elastomeric micropost arrays to modulate substrate rigidity independently of effects on adhesive and other material surface properties. We demonstrated that micropost rigidity impacts cell morphology, focal adhesions, cytoskeletal contractility and stem cell differentiation. Furthermore, early changes in cytoskeletal contractility predicted later stem cell fate decisions in single cells.

Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Present addresses: Department of Mechanical Engineering and Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA (J.F.) and Skeletal-Joint Research Center, National Cheng-Kung University Medical School, Tainan, Taiwan (Y.-K.W.).
These authors contributed equally to this work.

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