西亚试剂：Insulin-like Signaling Determines Survival during Stress vi

Insulin-like Signaling Determines Survival during Stress via Posttranscriptional Mechanisms in C. elegans
Gawain McColl, Aric N. Rogers, Silvestre Alavez, Alan E. Hubbard, Simon Melov, Christopher D. Link, Ashley I. Bush, Pankaj Kapahi, Gordon J. Lithgow

The insulin-like signaling (ILS) pathway regulates metabolism and is known to modulate adult life span in C. elegans. Altered stress responses and resistance to a wide range of stressors are also associated with changes in ILS and contribute to enhanced longevity. The transcription factors DAF-16 and HSF-1 are key effectors of the longevity phenotype. We demonstrate that increased intrinsic thermotolerance, due to lower ILS, is not dependent on stress-induced transcriptional responses but instead requires active protein translation. Translation profiling experiments reveal genes that are posttranscriptionally regulated in response to altered ILS during heat shock in a DAF-16-dependent manner. Furthermore, several novel proteins are specifically required for ILS effects on thermotolerance. We propose that lowered ILS results in metabolic and physiological changes. These DAF-16-induced changes precondition a translational response under acute stress to modulate survival.

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