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Histone methyltransferase G9a contributes to H3K27 methylation in vivo
Hui Wu, Xiuzhen Chen, Jun Xiong, Yingfeng Li, Hong Li, Xiaojun Ding, Sheng Liu, She Chen, Shaorong Gao and Bing Zhu
AbstractHistone modifications play a vital role in the conformation and function of their associated chromatin templates 1. Histone H3K27 methylation mediated by the PRC2 complex is critical for transcriptional regulation, Polycomb silencing, Drosophila segmentation, mammalian X inactivation and cancer 1.