西亚试剂：CO2 exacerbates oxygen toxicity

CO2 exacerbates oxygen toxicity

Benjamin Ezraty1, Ma?alène Chabalier1, Adrien Ducret1, Etienne Maisonneuve1 & Sam Dukan1

Aix Marseille Université, Laboratoire de Chimie Bactérienne (UPR 9043), Institut de Microbiologie de la Méditerranée (IFR88), CNRS, 31, Chemin Joseph Aiguier, 13402 Marseille, France

Reactive oxygen species (ROS) are harmful because they can oxidize biological macromolecules. We show here that atmospheric CO2 (concentration range studied: 40–1,000 p.p.m.) increases death rates due to H2O2 stress in Escherichia coli in a dose-specific manner. This effect is correlated with an increase in H2O2-induced mutagenesis and, as shown by 8-oxo-guanine determinations in cells, DNA base oxidation rates. Moreover, the survival of mutants that are sensitive to aerobic conditions (Hpx? dps and recA fur), presumably because of their inability to tolerate ROS, seems to depend on CO2 concentration. Thus, CO2 exacerbates ROS toxicity by increasing oxidative cellular lesions.

Keywords:carbon dioxide, DNA, Fenton reaction, oxidative stress, mutagenesis

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