西亚试剂：Rcor2 is a Subunit of the LSD1 Complex that Regulates ES Ce

Rcor2 is a Subunit of the LSD1 Complex that Regulates ES Cell Property and Substitutes for Sox2 in Reprogramming Somatic Cells to Pluripotency

Peng Yang, Yixuan Wang, Jiayu Chen, Hong Li, Lan Kang, Yu Zhang, She Chen, Bing Zhu, Shaorong Gao

Keywords:Histone demethylase;Rcor2;Pluripotency;Reprogramming

Abstract

Histone demethylase LSD1 can form complex with different Rcor family co-repressors in different cell types. It remains unknown if cell-specific Rcor proteins function specifically in distinct cell types. Here, we report that Rcor2 is predominantly expressed in ES cells and forms a complex with LSD1 and facilitates its nucleosomal demethylation activity. Knock-down of Rcor2 in ES cells inhibited ES cell proliferation and severely impaired the pluripotency. Moreover, knock-down of Rcor2 greatly impaired the formation of induced pluripotent stem (iPS) cells. In contrast, ectopic expression of Rcor2 in somatic cells together with Oct4, Sox2 and Klf4 promoted the formation of iPS cells. Most interestingly, ectopic expression of Rcor2 in both mouse and human somatic cells effectively substituted the requirement for exogenous Sox2 expression in somatic cell reprogramming.

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