西亚试剂：Drosophila katanin is a microtubule depolymerase that regul

Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

Dong Zhang,1 Kyle D. Grode,2, 5 Shannon F. Stewman,1, 5 Juan Daniel Diaz-Valencia,3, 5 Emily Liebling,1 Uttama Rath,1 Tania Riera,1 Joshua D. Currie,2 Daniel W. Buster,4 Ana B. Asenjo,1 Hernando J. Sosa,1 Jennifer L. Ross,3, 5 Ao Ma,1, 5 Stephen L. Rogers2, 5 & David J. Sharp1

Regulation of microtubule dynamics at the cell cortex is important for cell motility, morphogenesis and division. Here we show that the Drosophila katanin Dm-Kat60 functions to generate a dynamic cortical-microtubule interface in interphase cells. Dm-Kat60 concentrates at the cell cortex of S2 Drosophila cells during interphase, where it suppresses the polymerization of microtubule plus-ends, thereby preventing the formation of aberrantly dense cortical arrays. Dm-Kat60 also localizes at the leading edge of migratory D17 Drosophila cells and negatively regulates multiple parameters of their motility. Finally, in vitro, Dm-Kat60 severs and depolymerizes microtubules from their ends. On the basis of these data, we propose that Dm-Kat60 removes tubulin from microtubule lattice or microtubule ends that contact specific cortical sites to prevent stable and/or lateral attachments. The asymmetric distribution of such an activity could help generate regional variations in microtubule behaviours involved in cell migration.

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