西亚试剂：Pivotal Role of Dermal IL-17-Producing T Cells in Skin Infl

Pivotal Role of Dermal IL-17-Producing T Cells in Skin Inflammation

Yihua Cai, Xiaoyan Shen, Chuanlin Ding, Chunjian Qi, Kejia Li, Xia Li, Venkatakrishna R. Jala, Huang-ge Zhang, Tian Wang, Jie Zheng, Jun Yan

Interleukin-23 (IL-23) and CD4+ T helper 17 (Th17) cells are thought to be critical in psoriasis pathogenesis. Here, we report that IL-23 predominantly stimulated dermal T cells to produce IL-17 that led to disease progression. Dermal T cells constitutively expressed the IL-23 receptor (IL-23R) and transcriptional factor RORt. IL-17 production from dermal T cells was independent of T cells. The epidermal hyperplasia and inflammation induced by IL-23 were significantly decreased in T cell receptor-deficient (Tcrd/) and IL-17 receptor-deficient (Il17ra/) mice but occurred normally in Il17ra/ mice. Imiquimod-induced skin pathology was also significantly decreased in Il17ra/ mice. Perhaps further promoting disease progression, IL-23 stimulated dermal T cell expansion. In psoriasis patients, T cells were greatly increased in affected skin and produced large amounts of IL-17. Thus, IL-23-responsive dermal T cells are the major IL-17 producers in the skin and may represent a novel target for the treatment of psoriasis.

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