西亚试剂：Asymmetric B Cell Division in the Germinal Center Reaction

Asymmetric B Cell Division in the Germinal Center Reaction

Burton E. Barnett, Maria L. Ciocca, Radhika Goenka, Lisa G. Barnett, Junmin Wu, Terri M. Laufer, Janis K. Burkhardt, Michael P. Cancro, Steven L. Reiner

Lifelong antibody responses to vaccination require reorganization of lymphoid tissue and dynamic inter-cellular communication called the germinal center reaction. B lymphocytes undergo cellular polarization during antigen stimulation, acquisition, and presentation, which are critical steps for initiating humoral immunity. Here, we show that germinal center B lymphocytes asymmetrically segregate the transcriptional regulator Bcl6, the receptor for interleukin-21, and the ancestral polarity protein atypical PKC to one side of the plane of division, generating unequal inheritance of fate-altering molecules by daughter cells. Germinal center B lymphocytes from mice with a defect in leukocyte adhesion fail to divide asymmetrically. These results suggest that motile cells lacking constitutive attachment can receive provisional polarity cues from the micro-environment to generate daughter cell diversity and self-renewal.

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