西亚试剂：Nematode sperm maturation triggered by protease involves sp

Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin)

Yanmei Zhaoa, Wei Suna,b,1, Pan Zhangc,1, Hao Chib,d,1, Mei-Jun Zhangc,1, Chun-Qing Songc, Xuan Maa, Yunlong Shanga,b, Bin Wanga, Youqiao Hua,b, Zhiqi Haoe, Andreas F. Hühmere, Fanxia Menga, Steven W. L'Hernaultf, Si-Min Hed, Meng-Qiu Dongc,2, and Long Miaoa,2

Spermiogenesis is a series of poorly understood morphological, physiological and biochemical processes that occur during the transition of immotile spermatids into motile, fertilization-competent spermatozoa. Here, we identified a Serpin (serine protease inhibitor) family protein (As_SRP-1) that is secreted from spermatids during nematode Ascaris suum spermiogenesis (also called sperm activation) and we showed that As_SRP-1 has two major functions. First, As_SRP-1 functions in cis to support major sperm protein (MSP)-based cytoskeletal assembly in the spermatid that releases it, thereby facilitating sperm motility acquisition. Second, As_SRP-1 released from an activated sperm inhibits, in trans, the activation of surrounding spermatids by inhibiting vas deferens-derived As_TRY-5, a trypsin-like serine protease necessary for sperm activation. Because vesicular exocytosis is necessary to create fertilization-competent sperm in many animal species, components released during this process might be more important modulators of the physiology and behavior of surrounding sperm than was previously appreciated.

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