西亚试剂：CUL4B ubiquitin ligase in mouse development：A model for hum

CUL4B ubiquitin ligase in mouse development：A model for human X-linked mental retardation syndrome？

Yongchao Zhao1 and Yi Sun1

1Division of Radiation and Cancer Biology， Department of Radiation Oncology， University of Michigan， 4424B MS-1， 1301 Catherine Street， Ann Arbor， MI 48109， USA

Correspondence：Yi Sun，Tel： 734-615-1989；Fax：734-763-1581

CUL4B， a member of the cullin-RING ubiquitin ligase family， is frequently mutated in X-linked mental retardation (XLMR) patients. The study by Liu et al. showed that Cul4b plays an essential developmental role in the extra-embryonic tissues， while it is dispensable in the embryo proper during mouse embryogenesis. Viable Cul4b-null mice provide the first animal model to study neuronal and behavioral deficiencies seen in human CUL4B XLMR patients.

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