西亚试剂：Hox Genes Regulate Digit Patterning by Controlling the Wave

Hox Genes Regulate Digit Patterning by Controlling the Wavelength of a Turing-Type Mechanism

Rushikesh Sheth1,*,†, Luciano Marcon2,3,*, M. Félix Bastida1,4, Marisa Junco1, Laura Quintana2,3, Randall Dahn5, Marie Kmita6,‡, James Sharpe2,3,7,‡, Maria A. Ros1,4,‡

The formation of repetitive structures (such as stripes) in nature is often consistent with a reaction-diffusion mechanism, or Turing model, of self-organizing systems. We used mouse genetics to analyze how digit patterning (an iterative digit/nondigit pattern) is generated. We showed that the progressive reduction in Hoxa13 and Hoxd11-Hoxd13 genes (hereafter referred to as distal Hox genes) from the Gli3-null background results in progressively more severe polydactyly, displaying thinner and densely packed digits. Combined with computer modeling, our results argue for a Turing-type mechanism underlying digit patterning, in which the dose of distal Hox genes modulates the digit period or wavelength. The phenotypic similarity with fish-fin endoskeleton patterns suggests that the pentadactyl state has been achieved through modification of an ancestral Turing-type mechanism.

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