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西亚试剂:Structure of the type VI effector-immunity complex (Tae4-Ta

Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein

Heng Zhang1, Heng Zhang2, Zeng-Qiang Gao2, Wen-Jia Wang2, Guang-Feng Liu2, Jian-Hua Xu2, Xiao-Dong Su1 and Yu-Hui Dong2,*

Background: The bacteria effector Tae4 is injected into the recipient cells to kill them and the immunity protein Tai4 is produced to inactivate Tae4. Results: Tae4 displays a papain-like fold and Tai4 dimer is responsible for inhibiting Tae4 activity. Conclusion: The inactivation of Tae4 is required by collaboration of both subunits of Tai4 dimer. Significance: Our results add new insights into the effector-immunity interaction module.