西亚试剂：Amputation-induced reactive oxygen species are required for

Amputation-induced reactive oxygen species are required for successful Xenopus tadpole tail regeneration

Nick R. Love, Yaoyao Chen, Shoko Ishibashi, Paraskevi Kritsiligkou, Robert Lea, Yvette Koh, Jennifer L. Gallop, Karel Dorey & Enrique Amaya

Understanding the molecular mechanisms that promote successful tissue regeneration is critical for continued advancements in regenerative medicine. Vertebrate amphibian tadpoles of the speciesXenopus laevis and Xenopus tropicalis have remarkable abilities to regenerate their tails following amputation1, 2, through the coordinated activity of numerous growth factor signalling pathways, including the Wnt, Fgf, Bmp, Notch and TGF-β pathways3, 4, 5, 6. Little is known, however, about the events that act upstream of these signalling pathways following injury. Here, we show that Xenopustadpole tail amputation induces a sustained production of reactive oxygen species (ROS) during tail regeneration. Lowering ROS levels, using pharmacological or genetic approaches, reduces the level of cell proliferation and impairs tail regeneration. Genetic rescue experiments restored both ROS production and the initiation of the regenerative response. Sustained increased ROS levels are required for Wnt/β-catenin signalling and the activation of one of its main downstream targets,fgf20 (ref. 7), which, in turn, is essential for proper tail regeneration. These findings demonstrate that injury-induced ROS production is an important regulator of tissue regeneration.

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