西亚试剂：Sleep Drives Metabolite Clearance from the Adult Brain

Sleep Drives Metabolite Clearance from the Adult Brain

Lulu Xie1，*， Hongyi Kang1，*， Qiwu Xu1， Michael J. Chen1， Yonghong Liao1， Meenakshisundaram Thiyagarajan1， John O’Donnell1， Daniel J. Christensen1， Charles Nicholson2， Jeffrey J. Iliff1， Takahiro Takano1， Rashid Deane1， Maiken Nedergaard1

The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice， we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space， resulting in a striking increase in convective exchange of cerebrospinal fluid with interstitial fluid. In turn， convective fluxes of interstitial fluid increased the rate of β-amyloid clearance during sleep. Thus， the restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.

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