西亚试剂：Spatial organization within a niche as a determinant of ste

Spatial organization within a niche as a determinant of stem-cell fate

Panteleimon Rompolas，Kailin R. Mesa& Valentina Greco

Stem-cell niches in mammalian tissues are often heterogeneous and compartmentalized； however， whether distinct niche locations determine different stem-cell fates remains unclear. To test this hypothesis， here we use the mouse hair follicle niche and combine intravital microscopy with genetic lineage tracing to re-visit the same stem-cell lineages， from their exact place of origin， throughout regeneration in live mice. Using this method， we show directly that the position of a stem cell within the hair follicle niche can predict whether it is likely to remain uncommitted， generate precursors or commit to a differentiated fate. Furthermore， using laser ablation we demonstrate that hair follicle stem cells are dispensable for regeneration， and that epithelial cells， which do not normally participate in hair growth， re-populate the lost stem-cell compartment and sustain hair regeneration. This study provides a general model for niche-induced fate determination in adult tissues.

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