西亚试剂：miR-142-3p regulates the formation and differentiation of h

miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates

Xinyan Lu1，*， Xiajuan Li1，*， Qiuping He1， Jiao Gao2， Ya Gao1， Bing Liu2 and Feng Liu1

Previous studies on developmental hematopoiesis have mainly focused on signaling and transcription factors， while the appreciation of epigenetic regulation including that of microRNAs is recent. Here， we show that in zebrafish and mouse， miR-142-3p is specifically expressed in hematopoietic stem cells (HSCs). Knockdown of miR-142a-3p in zebrafish led to a reduced population of HSCs in the aorta-gonad-mesonephros (AGM) region as well as T-cell defects in the thymus. Mechanistically， miR-142a-3p regulates HSC formation and differentiation through the repression of interferon regulatory factor 7 (irf7)-mediated inflammation signaling. Finally， we show that miR-142-3p is also involved in the development of HSCs in mouse AGM， suggesting that it has a highly conserved role in vertebrates. Together， these findings unveil the pivotal roles that miR-142a-3p plays in the formation and differentiation of HSCs by repressing irf7 signaling.

• 以上资料由西亚试剂：http://www.xiyashiji.com/ 提供此产品的详细信息如密度,含量,分子式,分子量等均可在西亚官网查询   
• 相关产品如诺卡氏菌液(-)-樟脑神经鞘磷脂,从牛脑所得 杨梅苷愈创奥IAPN-叔丁基苯硫腈氯化物4-溴苯基五氟化硫色胺盐酸盐4-溴噻吩-2-甲醛纤维素粉 7-(二甲基氨基)-4-三氟甲基香豆素邻硝基苯肼盐酸盐3,3'-二氨基联苯胺四盐酸盐水合物美伐他汀丁卡因阿卡明全氟辛基季胺碘化物布西拉明硫酸多粘菌素B益母草浸膏黄苓干膏 L-2,3-二氨基丙酸盐酸盐黄糊精EB替代品(GoldView)等均有销售.欢迎订购