西亚试剂：Nematode-derived drosomycin-type antifungal peptides provid

Nematode-derived drosomycin-type antifungal peptides provide evidence for plant-to-ecdysozoan horizontal transfer of a disease resistance gene

Shunyi Zhu  & Bin Gao

Drosomycin-type antifungal peptides (DTAFPs) are key innate immunity components of Drosophila and plants and confer resistance to fungal infection. Here we report the discovery of a multigene family of DTAFPs， comprising of 15 members (termed cremycin-1 to crymycin-15)， in the fruit nematode Caenorhabditis remanei. Cremycins share highly similar amino-acid sequences and identical precursor organization to drosomycins. Of the 15 cremycin genes， 10 are found to be transcriptionally active and 6 are upregulated after fungal challenge. Synthetic cremycin-5 is active on filamentous fungi and a series of clinical isolates of human pathogenic yeasts and exhibits low haemolysis and high serum stability. The specific distribution of DTAFPs in a clade of moulting animals (Ecdysozoa)， including Arthropoda， Nematoda and Tardigrada， together with the widespread presence in plants but the absence in fungi and protozoans， provides evidence for horizontal transfer of a disease resistance gene between plants and ecdysozoans.

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