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Antiviral RNAi in mammals
Darren J. Burgess
The cleavage of viral double-stranded RNAs (dsRNAs) by host RNA interference (RNAi) machinery has been shown to be an important antiviral mechanism in various species, including in plants and insects. However, in mammals, it was unclear whether RNAi had a similar role or whether alternative antiviral mechanisms, such as the interferon response, predominate.…