西亚试剂：Human colorectal cancer-specific CCAT1-L lncRNA regulates l

Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus

Jian-Feng Xiang1， Qing-Fei Yin1， Tian Chen1， Yang Zhang1， Xiao-Ou Zhang2， Zheng Wu1， Shaofeng Zhang1， Hai-Bin Wang3， Junhui Ge3， Xuhua Lu3， Li Yang2 and Ling-Ling Chen1

The human 8q24 gene desert contains multiple enhancers that form tissue-specific long-range chromatin loops with the MYC oncogene， but how chromatin looping at the MYC locus is regulated remains poorly understood. Here we demonstrate that a long noncoding RNA (lncRNA)， CCAT1-L， is transcribed specifically in human colorectal cancers from a locus 515 kb upstream of MYC. This lncRNA plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly， the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition， CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. These results reveal an important role of a previously unannotated lncRNA in gene regulation at the MYC locus.

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